• NCI-N87人胃癌细胞(STR鉴定正确)

    价 格:¥1800

    期 货:现货(冻存管发2支)

    保藏中心☝🏼:BTCC

    资源编号:BTCC-1137

    产地:中国

    套 餐:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameNCI-N87
    SynonymsNCI N87; N87; N-87; NCI-H87; H87; H-87; NCIN87
    AccessionBTCC-1137
    Resource Identification InitiativeTo cite this cell line use: NCI-N87 (BTCC-1137)
    CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
    Part of: COSMIC cell lines project.
    Part of: MET genetic alteration cell panel (ATCC TCP-1036).
    Characteristics: Established from a nude mouse xenograft.
    Doubling time: 47 hours (PubMed=2158397); 86 hours (PubMed=25984343); 23 hours (PubMed=26919099).
    Microsatellite instability: Stable (MSS) (Sanger).
    Omics: Deep exome analysis.
    Omics: Deep quantitative proteome analysis.
    Omics: DNA methylation analysis.
    Omics: shRNA library screening.
    Omics: SNP array analysis.
    Omics: Transcriptome analysis by microarray.
    Omics: Transcriptome analysis by RNAseq.
    Misspelling: NU-N87; BioSample=SAMN01120666; PubMed=25960936; Note=Also in all the NCBI data records associated with the BioSample record.
    Derived from site: Metastatic; Liver; UBERON=UBERON_0002107.
    Sequence variations
    • Gene deletion; HGNC; 6770; SMAD4; Zygosity=Homozygous (ATCC).
    • Mutation; HGNC; 3431; ERBB3; Simple; p.Thr757Lys (c.2270C>A); Zygosity=Unspecified (PubMed=26919099).
    • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (PubMed=1676761; ATCC).
    HLA typingSource: PubMed=25960936
    Class I
    HLA-AA*01:01,23:01
    HLA-BB*07:02,37:01
    HLA-CC*02:02,07:02
    Class II
    HLA-DQDQB1*05:02,05:02
    HLA-DRDRB1*15:01,15:01

    Source: PubMed=26589293
    Class I
    HLA-AA*23:01,23:01
    HLA-BB*07:02,37:01
    HLA-CC*02:02,02:02
    Genome ancestrySource: PubMed=30894373

    Origin% genome


    African61.23
    Native American0
    East Asian, North2.17
    East Asian, South0
    South Asian0
    European, North20.57
    European, South16.04
    DiseaseGastric tubular adenocarcinoma (NCIt: C5473)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    HierarchyChildren:



    CVCL_JY25 (NCI-hTERT-CL5)CVCL_JY26 (NCI-hTERT-CL6)CVCL_WH01 (NCI-N87 HR)
    CVCL_XZ59 (NCI-N87 human CLDN18.2)CVCL_IL03 (NCI-N87/TR)
    Sex of cellMale
    Age at samplingAge unspecified
    CategoryCancer cell line
    STR profileSource(s): AddexBio; ATCC; CCRID; Cosmic-CLP; Genomics_Center_BCF_Technion; PubMed=25877200; PubMed=27102572

    Markers:
    AmelogeninX,Y
    CSF1PO8,12
    D1S165616
    D2S44111,12
    D2S133823,24
    D3S135814
    D5S81812,13
    D6S104312
    D7S82010,11
    D8S117914,15
    D10S124813
    D12S39116,21
    D13S3178,11
    D16S5399,13
    D18S5117
    D19S43314,14.2
    D21S1130
    D22S104514,15
    DYS39110
    FGA20,21
    Penta D12
    Penta E5
    TH017,9 (PubMed=27102572)
    9 (AddexBio; ATCC; CCRID; Cosmic-CLP; Genomics_Center_BCF_Technion; PubMed=25877200)
    TPOX9,11
    vWA15,16

    Run an STR similarity search on this cell line
    Web pageshttps://www.atcc.org/en/support/technical-support/faqs/normal-morphology-and-growth-of-crl-5822-cells
    Publications

    PubMed=2158397
    Park J.-G., Frucht H., La Rocca R.V., Bliss D.P. Jr., Kurita Y., Chen T.-R., Henslee J.G., Trepel J.B., Jensen R.T., Johnson B.E., Bang Y.-J., Kim J.-P., Gazdar A.F.
    Characteristics of cell lines established from human gastric carcinoma.
    Cancer Res. 50:2773-2780(1990)

    PubMed=1676761; DOI=10.1093/jnci/83.13.938
    Kim J.-H., Takahashi T., Chiba I., Park J.-G., Birrer M.J., Roh J.K., De Lee H., Kim J.-P., Minna J.D., Gazdar A.F.
    Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines.
    J. Natl. Cancer Inst. 83:938-943(1991)

    DOI=10.1016/B978-0-12-333530-2.50014-9
    Sekiguchi M., Suzuki T.
    Gastric tumor cell lines.
    (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York (1994)

    PubMed=8806089; DOI=10.1002/jcb.240630502
    Gazdar A.F., Minna J.D.
    NCI series of cell lines: an historical perspective.
    J. Cell. Biochem. 63 Suppl. 24:1-11(1996)

    PubMed=8806092; DOI=10.1002/jcb.240630505
    Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
    NCI-Navy Medical Oncology Branch cell line data base.
    J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

    PubMed=8806095; DOI=10.1002/jcb.240630508
    Park J.-G., Gazdar A.F.
    Biology of colorectal and gastric cancer cell lines.
    J. Cell. Biochem. 63 Suppl. 24:131-141(1996)

    PubMed=18804159; DOI=10.1016/j.ygeno.2008.08.002
    Jung J.-J., Jeung H.-C., Chung H.C., Lee J.O., Kim T.S., Kim Y.T., Noh S.H., Rha S.Y.
    In vitro pharmacogenomic database and chemosensitivity predictive genes in gastric cancer.
    Genomics 93:52-61(2009)

    PubMed=20164919; DOI=10.1038/nature08768
    Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
    Signatures of mutation and selection in the cancer genome.
    Nature 463:893-898(2010)

    PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
    Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
    A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
    Cancer Res. 70:2158-2164(2010)

    PubMed=22460905; DOI=10.1038/nature11003
    Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
    The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
    Nature 483:603-607(2012)

    PubMed=24807215; DOI=10.1038/ncomms4830
    Liu J.-F., McCleland M.L., Stawiski E.W., Gnad F., Mayba O., Haverty P.M., Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., Liu H.-B., Wan Y.-N., Chopra V.S., Yaylaoglu M.B., Yuan W.-L., Ha C., Gilbert H.N., Reeder J., Pau G., Stinson J., Stern H.M., Manning G., Wu T.D., Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., Firestein R., Zhang Z.-M.
    Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
    Nat. Commun. 5:3830.1-3830.8(2014)

    PubMed=25960936; DOI=10.4161/21624011.2014.954893
    Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
    A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
    OncoImmunology 3:e954893.1-e954893.12(2014)

    PubMed=25984343; DOI=10.1038/sdata.2014.35
    Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
    Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
    Sci. Data 1:140035-140035(2014)

    PubMed=25485619; DOI=10.1038/nbt.3080
    Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
    A comprehensive transcriptional portrait of human cancer cell lines.
    Nat. Biotechnol. 33:306-312(2015)

    PubMed=26589293; DOI=10.1186/s13073-015-0240-5
    Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
    TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
    Genome Med. 7:118.1-118.7(2015)

    PubMed=26919099; DOI=10.18632/oncotarget.7575
    Arienti C., Zanoni M., Pignatta S., Del Rio A., Carloni S., Tebaldi M., Tedaldi G., Tesei A.
    Preclinical evidence of multiple mechanisms underlying trastuzumab resistance in gastric cancer.
    Oncotarget 7:18424-18439(2016)

    PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
    Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
    A landscape of pharmacogenomic interactions in cancer.
    Cell 166:740-754(2016)

    PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
    Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
    An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
    Cancer Res. 79:1263-1273(2019)

    PubMed=31068700; DOI=10.1038/s41586-019-1186-3
    Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
    Next-generation characterization of the Cancer Cell Line Encyclopedia.
    Nature 569:503-508(2019)

    PubMed=31803961; DOI=10.1002/jcb.29564
    Mulshine J.L., Ujhazy P., Antman M., Burgess C.M., Kuzmin I., Bunn P.A. Jr., Johnson B.E., Roth J.A., Pass H.I., Ross S.M., Aldige C.R., Wistuba I.I., Minna J.D.
    From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.
    J. Cell. Biochem. 121:3986-3999(2020)

    PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
    Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
    Quantitative proteomics of the Cancer Cell Line Encyclopedia.
    Cell 180:387-402.e16(2020)

    PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
    Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
    Pan-cancer proteomic map of 949 human cell lines.
    Cancer Cell 40:835-849.e8(2022)

    Cross-references
    Cell line databases/resourcesCLO; CLO_0008129
    CCRID; 1101HUM-PUMC000481
    CCRID; 3101HUMSCSP534
    CCRID; 3101HUMTCHu130
    CCRID; 4201HUM-CCTCC00256
    Cell_Model_Passport; SIDM01147
    Cosmic-CLP; 908461
    DepMap; ACH-000427
    LINCS_LDP; LCL-1886
    Anatomy/cell type resourcesBTO; BTO:0003053
    Biological sample resourcesBioSample; SAMN01120666
    BioSample; SAMN03473211
    BioSample; SAMN10987913
    Cell line collections (Providers)AddexBio; C0023002/4674
    ATCC; CRL-5822
    BCRC; 60217
    BCRJ; 0350
    CCTCC; GDC0256
    CLS; 305057
    IZSLER; BS TCL 224
    KCB; KCB 2010183YJ
    KCLB; 60113
    KCLB; 60187 - Discontinued
    Chemistry resourcesChEMBL-Cells; CHEMBL3307326
    ChEMBL-Targets; CHEMBL614197
    GDSC; 908461
    PharmacoDB; NCIN87_1151_2019
    PubChem_Cell_line; CVCL_1603
    Encyclopedic resourcesWikidata; Q54908217
    Experimental variables resourcesEFO; EFO_0002841

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