• NCI-H2444人非小细胞肺癌细胞(STR鉴定正确)

    价 格:¥2400

    期 货◀️🪘:现货(冻存管发2支)

    保藏中心:BTCC

    资源编号:BTCC-1442

    产地🎾:中国

    套 餐:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameNCI-H2444
    SynonymsH2444; H-2444; NCIH244
    AccessionBTCC-1442
    Resource Identification InitiativeTo cite this cell line use: NCI-H2444 (RRID:BTCC-1442)
    CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
    Part of: COSMIC cell lines project.
    Part of: NCI RAS program mutant KRAS cell line panel.
    Population: Caucasian.
    Microsatellite instability: Stable (MSS) (Sanger).
    Omics: Genomics; DNA methylation analysis.
    Omics: Genomics; Whole exome sequencing.
    Omics: Phenotyping; Drug screening.
    Omics: Proteomics.
    Omics: Proteomics; Expression; Reverse-phase protein array.
    Omics: Proteomics; Quantitative.
    Omics: Transcriptomics; Microarray.
    Omics: Transcriptomics; RNAseq.
    Omics: Variations; SNP array analysis.
    Derived from site: In situ; Lung; UBERON=UBERON_0002048.
    Sequence variations
    • Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (Cosmic-CLP=1298356; DepMap=ACH-000186).
    • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr236Cys (c.707A>G); ClinVar=VCV000376693; Zygosity=Homozygous (Cosmic-CLP=1298356; DepMap=ACH-000186).
    HLA typingSource: PubMed=26589293
    Class I
    HLA-AA*03:01,03:01
    HLA-BB*07:02,07:02
    HLA-CC*07:02,07:02
    Genome ancestrySource: PubMed=30894373

    Origin% genome


    African0
    Native American1.22
    East Asian, North3
    East Asian, South0
    South Asian1.26
    European, North58.66
    European, South35.85
    DiseaseLung non-small cell carcinoma (NCIt: C2926)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    Sex of cellMale
    Age at samplingAge unspecified
    CategoryCancer cell line
    STR profileSource(s): AddexBio=C0016038/5010; ATCC=CRL-5945; Cosmic-CLP=1298356; PubMed=25877200; PubMed=31467290

    Markers:
    AmelogeninX
    CSF1PO12
    D2S133820 (PubMed=31467290)
    20,25 (ATCC=CRL-5945)
    D3S135814
    D5S81810
    D7S8208 (PubMed=25877200)
    8,10 (AddexBio=C0016038/5010; ATCC=CRL-5945; Cosmic-CLP=1298356; PubMed=31467290)
    D8S117911,12,13 (ATCC=CRL-5945; PubMed=25877200)
    12,13 (PubMed=31467290)
    D13S31711,12
    D16S53912
    D18S5113
    D19S43316 (ATCC=CRL-5945)
    16,17 (PubMed=31467290)
    D21S1128,29
    FGA25
    Penta D9,12
    Penta E5
    TH019.3
    TPOX11
    vWA17

    Run an STR similarity search on this cell line
    Publications

    PubMed=8806092; DOI=10.1002/jcb.240630505
    Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
    NCI-Navy Medical Oncology Branch cell line data base.
    J. Cell. Biochem. Suppl. 24:32-91(1996)

    PubMed=11030152; DOI=10.1038/sj.onc.1203815
    Modi S., Kubo A., Oie H.K., Coxon A.B., Rehmatulla A., Kaye F.J.
    Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer.
    Oncogene 19:4632-4639(2000)

    PubMed=18083107; DOI=10.1016/j.cell.2007.11.025
    Rikova K., Guo A.-L., Zeng Q.-F., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y.-R., Tan Z.-P., Stokes M.P., Sullivan L., Mitchell J., Wetzel R., MacNeill J., Ren J.-M., Yuan J., Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D.-Q., Zhou X.-M., Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.
    Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer.
    Cell 131:1190-1203(2007)

    PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
    Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
    The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
    Nature 483:603-607(2012)

    PubMed=22961666; DOI=10.1158/2159-8290.CD-12-0112; PMCID=PMC3567922
    Byers L.A., Wang J., Nilsson M.B., Fujimoto J., Saintigny P., Yordy J.S., Giri U., Peyton M., Fan Y.-H., Diao L.-X., Masrorpour F., Shen L., Liu W.-B., Duchemann B., Tumula P., Bhardwaj V., Welsh J., Weber S., Glisson B.S., Kalhor N., Wistuba I.I., Girard L., Lippman S.M., Mills G.B., Coombes K.R., Weinstein J.N., Minna J.D., Heymach J.V.
    Proteomic profiling identifies dysregulated pathways in small cell lung cancer and novel therapeutic targets including PARP1.
    Cancer Discov. 2:798-811(2012)

    PubMed=25877200; DOI=10.1038/nature14397
    Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
    A resource for cell line authentication, annotation and quality control.
    Nature 520:307-311(2015)

    PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
    Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
    TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
    Genome Med. 7:118.1-118.7(2015)

    PubMed=26361996; DOI=10.1016/j.jprot.2015.09.003
    Grundner-Culemann K., Dybowski J.N., Klammer M., Tebbe A., Schaab C., Daub H.
    Comparative proteome analysis across non-small cell lung cancer cell lines.
    J. Proteomics 130:1-10(2016)

    PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
    Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
    A landscape of pharmacogenomic interactions in cancer.
    Cell 166:740-754(2016)

    PubMed=29681454; DOI=10.1016/j.cell.2018.03.028; PMCID=PMC5935540
    McMillan E.A., Ryu M.-J., Diep C.H., Mendiratta S., Clemenceau J.R., Vaden R.M., Kim J.-H., Motoyaji T., Covington K.R., Peyton M., Huffman K., Wu X.-F., Girard L., Sung Y., Chen P.-H., Mallipeddi P.L., Lee J.Y., Hanson J., Voruganti S., Yu Y., Park S., Sudderth J., DeSevo C., Muzny D.M., Doddapaneni H., Gazdar A.F., Gibbs R.A., Hwang T.H., Heymach J.V., Wistuba I.I., Coombes K.R., Williams N.S., Wheeler D.A., MacMillan J.B., DeBerardinis R.J., Roth M.G., Posner B.A., Minna J.D., Kim H.S., White M.A.
    Chemistry-first approach for nomination of personalized treatment in lung cancer.
    Cell 173:864-878.e29(2018)

    PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
    Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
    An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
    Cancer Res. 79:1263-1273(2019)

    PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
    Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
    Next-generation characterization of the Cancer Cell Line Encyclopedia.
    Nature 569:503-508(2019)

    PubMed=31467290; DOI=10.1038/s41597-019-0166-7; PMCID=PMC6715692
    Schoenherr R.M., Huang D.-Q., Voytovich U.J., Ivey R.G., Kennedy J.J., Saul R.G., Colantonio S., Roberts R.R., Knotts J.G., Kaczmarczyk J.A., Perry C., Hewitt S.M., Bocik W., Whiteley G.R., Hiltke T., Boja E.S., Rodriguez H., Whiteaker J.R., Paulovich A.G.
    A dataset describing a suite of novel antibody reagents for the RAS signaling network.
    Sci. Data 6:160.1-160.11(2019)

    PubMed=31803961; DOI=10.1002/jcb.29564; PMCID=PMC7496084
    Mulshine J.L., Ujhazy P., Antman M., Burgess C.M., Kuzmin I.A., Bunn P.A. Jr., Johnson B.E., Roth J.A., Pass H.I., Ross S.M., Aldige C.R., Wistuba I.I., Minna J.D.
    From clinical specimens to human cancer preclinical models -- a journey the NCI-cell line database-25 years later.
    J. Cell. Biochem. 121:3986-3999(2020)

    PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
    Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
    Pan-cancer proteomic map of 949 human cell lines.
    Cancer Cell 40:835-849.e8(2022)

    Cross-references
    Cell line collections (Providers)AddexBio; C0016038/5010
    ATCC; CRL-5945
    Cell line databases/resourcesCLO; CLO_0008076
    cancercelllines; CVCL_1552
    Cell_Model_Passport; SIDM00723
    Cosmic-CLP; 1298356
    DepMap; ACH-000186
    IGRhCellID; H2444GEO
    LINCS_LDP; LCL-1621
    Biological sample resourcesBioSample; SAMN03472608
    BioSample; SAMN03473022
    BioSample; SAMN10988376
    Chemistry resourcesChEMBL-Cells; CHEMBL4523548
    ChEMBL-Targets; CHEMBL4523579
    GDSC; 1298356
    PharmacoDB; NCIH2444_1091_2019
    PubChem_Cell_line; CVCL_1552
    Encyclopedic resourcesWikidata; Q54907974
    Gene expression databasesArrayExpress; E-MTAB-2770
    ArrayExpress; E-MTAB-3610
    GEO; GSM434295
    GEO; GSM887423
    GEO; GSM888502
    GEO; GSM1374738
    GEO; GSM1670233
    GEO; GSM1682810
    Polymorphism and mutation databasesCosmic; 1146908
    Cosmic; 1995570
    IARC_TP53; 28321
    LiGeA; CCLE_239
    Progenetix; CVCL_1552


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