• 143B人胸腺激酶缺陷细胞(STR鉴定正确)

    价 格:¥1800

    期 货:现货(冻存管发2支)

    保藏中心:BTCC

    资源编号🏄🏽:BTCC-1252

    产地👳🏼:中国

    套 餐:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line name143B
    Synonyms143b; 143 B; 143B TK-; 143B.TK-; 143BTK-; 143TK-; HOS-143B; HOS-143b; GM05887; GM05887A
    AccessionBTCC-1252
    Resource Identification InitiativeTo cite this cell line use: 143B (BTCC-1252)
    CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
    Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8303.
    Population: Caucasian.
    Omics: Deep exome analysis.
    Omics: H3K4me1 ChIP-seq epigenome analysis.
    Omics: H3K27ac ChIP-seq epigenome analysis.
    Omics: SNP array analysis.
    Omics: Transcriptome analysis by microarray.
    Omics: Transcriptome analysis by RNAseq.
    Caution: Could be identical to HTK- (Cellosaurus=CVCL_2522).
    Misspelling: I43B; Cosmic=1529910.
    Derived from site: In situ; Bone, right femur; UBERON=UBERON_0000981.
    Sequence variations
    • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=19787792).
    • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Heterozygous (DepMap).
    • Mutation; HGNC; 6407; KRAS; Simple; p.Ala59Thr (c.175G>A); ClinVar=VCV000012581; Zygosity=Heterozygous (DepMap).
    • Mutation; HGNC; 11998; TP53; Simple; p.Arg156Pro (c.467G>C); ClinVar=VCV000634768; Zygosity=Homozygous (PubMed=19787792; DepMap).
    HLA typingSource: PubMed=26589293
    Class I
    HLA-AA*02:11,02:11
    HLA-BB*52:01,52:01
    HLA-CC*12:02,12:02
    Class II
    HLA-DQDQB1*05:02,05:02
    HLA-DRDRB1*15:02,16:05
    Genome ancestrySource: PubMed=30894373

    Origin% genome


    African0
    Native American0
    East Asian, North0
    East Asian, South4.02
    South Asian37
    European, North0
    European, South58.98
    DiseaseOsteosarcoma (NCIt: C9145)
    Osteosarcoma (ORDO: Orphanet_668)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    HierarchyParent: CVCL_0312 (HOS)
    Children:



    CVCL_3476 (143.98.2)CVCL_3477 (143B pML BK TK)CVCL_ZL52 (143B rho-0 EtBr)
    CVCL_XF76 (143B rho-0#25)CVCL_C0Q7 (143B-GFP-HK2)CVCL_U923 (143B.206)
    CVCL_9W36 (143BTK-)CVCL_IW03 (GM16530)CVCL_C6V0 (HOS-143B/CISR8)
    CVCL_C6V1 (HOS-143B/DOXR8)CVCL_C6V2 (HOS-143B/MTXR8)CVCL_C6V3 (HOS-143B/TRIR8)
    Sex of cellFemale
    Age at sampling13Y
    CategoryCancer cell line
    STR profileSource(s): ATCC; BCRC; CCRID; ECACC; PubMed=19787792; PubMed=25877200

    Markers:
    AmelogeninX
    CSF1PO12
    D2S133824,25
    D3S135815
    D5S81813 (ATCC; BCRC; CCRID; ECACC; PubMed=25877200)
    13,14 (PubMed=19787792)
    D7S82011,12
    D8S117911,14
    D13S31712
    D16S53910,13
    D18S5117
    D19S43313
    D21S1131.2,32.2
    FGA24
    Penta D9,10
    Penta E7,12
    SE3321
    TH016
    TPOX11
    vWA18 (ATCC; BCRC; CCRID; ECACC; PubMed=25877200)
    18,19 (PubMed=19787792)

    Run an STR similarity search on this cell line
    Web pageshttps://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/1/cell-lines-detail-310.html
    Publications

    PubMed=2233717; DOI=10.1128/mcb.10.11.5772-5781.1990
    Diller L., Kassel J., Nelson C.E., Gryka M.A., Litwak G., Gebhardt M., Bressac B., Ozturk M., Baker S.J., Vogelstein B., Friend S.H.
    p53 functions as a cell cycle control protein in osteosarcomas.
    Mol. Cell. Biol. 10:5772-5781(1990)

    CLPUB00447
    Mulivor R.A., Suchy S.F.
    1992/1993 catalog of cell lines. NIGMS human genetic mutant cell repository. 16th edition. October 1992.
    (In) Institute for Medical Research (Camden, N.J.) NIH 92-2011; pp.1-918; National Institutes of Health; Bethesda (1992)

    PubMed=19787792; DOI=10.1002/gcc.20717
    Ottaviano L., Schaefer K.-L., Gajewski M., Huckenbeck W., Baldus S., Rogel U., Mackintosh C., de Alava E., Myklebost O., Kresse S.H., Meza-Zepeda L.A., Serra M., Cleton-Jansen A.-M., Hogendoorn P.C.W., Buerger H., Aigner T., Gabbert H.E., Poremba C.
    Molecular characterization of commonly used cell lines for bone tumor research: a trans-European EuroBoNet effort.
    Genes Chromosomes Cancer 49:40-51(2010)

    PubMed=21519327; DOI=10.1038/labinvest.2011.72
    Mohseny A.B., Machado I., Cai Y., Schaefer K.-L., Serra M., Hogendoorn P.C.W., Llombart-Bosch A., Cleton-Jansen A.-M.
    Functional characterization of osteosarcoma cell lines provides representative models to study the human disease.
    Lab. Invest. 91:1195-1205(2011)

    PubMed=22460905; DOI=10.1038/nature11003
    Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
    The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
    Nature 483:603-607(2012)

    PubMed=25485619; DOI=10.1038/nbt.3080
    Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
    A comprehensive transcriptional portrait of human cancer cell lines.
    Nat. Biotechnol. 33:306-312(2015)

    PubMed=26320182; DOI=10.18632/oncotarget.5177
    Ren L., Mendoza A., Zhu J., Briggs J.W., Halsey C., Hong E.S., Burkett S.S., Morrow J.J., Lizardo M.M., Osborne T., Li S.Q., Luu H.-H., Meltzer P.S., Khanna C.
    Characterization of the metastatic phenotype of a panel of established osteosarcoma cells.
    Oncotarget 6:29469-29481(2015)

    PubMed=26589293; DOI=10.1186/s13073-015-0240-5
    Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
    TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
    Genome Med. 7:118.1-118.7(2015)

    PubMed=26852163; DOI=10.1074/mcp.M115.053181
    Aretz I., Hardt C., Wittig I., Meierhofer D.
    An impaired respiratory electron chain triggers down-regulation of the energy metabolism and de-ubiquitination of solute carrier amino acid transporters.
    Mol. Cell. Proteomics 15:1526-1538(2016)

    PubMed=29334376; DOI=10.1038/nm.4475
    Morrow J.J., Bayles I., Funnell A.P.W., Miller T.E., Saiakhova A., Lizardo M.M., Bartels C.F., Kapteijn M.Y., Hung S., Mendoza A., Dhillon G., Chee D.R., Myers J.T., Allen F., Gambarotti M., Righi A., DiFeo A., Rubin B.P., Huang A.Y., Meltzer P.S., Helman L.J., Picci P., Versteeg H.H., Stamatoyannopoulos J.A., Khanna C., Scacheri P.C.
    Positively selected enhancer elements endow osteosarcoma cells with metastatic competence.
    Nat. Med. 24:176-185(2018)

    PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
    Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
    An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
    Cancer Res. 79:1263-1273(2019)

    PubMed=31068700; DOI=10.1038/s41586-019-1186-3
    Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
    Next-generation characterization of the Cancer Cell Line Encyclopedia.
    Nature 569:503-508(2019)

    PubMed=36480329; DOI=10.1002/adbi.202200194
    Low K., Hills F., Roberts H.C., Stordal B.
    Establishment and characterization of single and triple-agent resistant osteosarcoma cell lines.
    Adv. Biol. (Weinh.) 0:e2200194.1-e2200194.13(2023)

    Cross-references
    Cell line databases/resourcesCLO; CLO_0001084
    CLO; CLO_0001088
    CLO; CLO_0024221
    CLDB; cl10
    CLDB; cl11
    CCRID; 1101HUM-PUMC000363
    CCRID; 4201HUM-CCTCC00076
    Cell_Model_Passport; SIDM00804
    DepMap; ACH-001001
    LINCS_LDP; LCL-1417
    Lonza; 136
    TOKU-E; 132
    Anatomy/cell type resourcesBTO; BTO:0003167
    Biological sample resourcesBioSample; SAMN03471904
    Cell line collections (Providers)ATCC; CRL-8303
    BCRC; 60439
    CCTCC; GDC0076
    Coriell; GM05887
    ECACC; 91112502
    IZSLER; BS TCL 77
    Chemistry resourcesChEMBL-Cells; CHEMBL3307382
    ChEMBL-Targets; CHEMBL614508
    PharmacoDB; 143B_3_2019
    PubChem_Cell_line; CVCL_2270
    Encyclopedic resourcesWikidata; Q54581813
    Experimental variables resourcesEFO; EFO_0006355

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