• Rs4;11人急性淋巴白血病细胞(STR鉴定正确)

    价 格🙋🏻‍♂️:¥1800

    期 货:现货(冻存管发2支)

    保藏中心👷🏿‍♂️:BTCC

    资源编号:BTCC-1264

    产地:中国

    套 餐:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameRS4;11
    SynonymsRS4-11; RS4:11; RS 4;11; RS(4;11); RS411
    AccessionBTCC-1264
    Resource Identification InitiativeTo cite this cell line use: RS4;11 (BTCC-1264)
    CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
    Part of: COSMIC cell lines project.
    Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.
    Doubling time: 35 hours (PubMed=20922763); 60 hours (PubMed=25984343); ~50 hours (DSMZ=ACC-508).
    Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
    Omics: Array-based CGH.
    Omics: Deep exome analysis.
    Omics: Deep quantitative phosphoproteome analysis.
    Omics: DNA methylation analysis.
    Omics: shRNA library screening.
    Omics: SNP array analysis.
    Omics: Transcriptome analysis by microarray.
    Omics: Transcriptome analysis by RNAseq.
    Misspelling: RS-E11; Cosmic=2131570.
    Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
    Sequence variations
    • Gene fusion; HGNC; 7135; AFF1 + HGNC; 7132; KMT2A; Name(s)=KMT2A-AFF1, MLL-AFF1, ALL-1/AF4; Note=In frame (PubMed=1423625; PubMed=8358709; PubMed=32721124).
    HLA typingSource: PubMed=26589293
    Class I
    HLA-AA*03:01,32:01
    HLA-BB*14:02,37:01
    HLA-CC*06:02,08:02
    Genome ancestrySource: PubMed=30894373

    Origin% genome


    African0
    Native American0.02
    East Asian, North0
    East Asian, South1.26
    South Asian1.83
    European, North65.49
    European, South31.4
    DiseaseAdult B acute lymphoblastic leukemia (NCIt: C9143)
    B acute lymphoblastic leukemia with t(v;11q23.3) MLL rearranged (NCIt: C80342)
    B-lymphoblastic leukemia/lymphoma with t(v;11q23.3) (ORDO: Orphanet_585918)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    HierarchyChildren:


    CVCL_XZ61 (RS4;11 BCL2-F104L)CVCL_XZ62 (RS4;11 BCL2-G101V)
    Sex of cellFemale
    Age at sampling32Y
    CategoryCancer cell line
    STR profileSource(s): AddexBio; ATCC; COG; Cosmic-CLP; DSMZ; PubMed=20922763; PubMed=25877200

    Markers:
    AmelogeninX
    CSF1PO11,12
    D2S133820,25
    D3S135815,17
    D5S81812 (DSMZ)
    12,13 (AddexBio; ATCC; COG; Cosmic-CLP; PubMed=20922763; PubMed=25877200)
    D7S8208,12
    D8S117913,14
    D13S31711
    D16S53911,12
    D18S5112,16
    D19S43312,14
    D21S1128,30
    FGA23,24,25 (DSMZ)
    24,25 (COG; PubMed=25877200)
    Penta D8.4,10
    Penta E5,7
    TH016,9.3
    TPOX8
    vWA14,17

    Run an STR similarity search on this cell line
    Web pageshttp://www.cccells.org/cellreqs-ncipptp.php
    http://www.pptpinvitro.org/cell_lines_panel.php
    Publications

    PubMed=3917311; DOI=10.1182/blood.V65.1.21.21
    Stong R.C., Korsmeyer S.J., Parkin J.L., Arthur D.C., Kersey J.H.
    Human acute leukemia cell line with the t(4;11) chromosomal rearrangement exhibits B lineage and monocytic characteristics.
    Blood 65:21-31(1985)

    PubMed=1720549; DOI=10.1073/pnas.88.23.10735
    Ziemin-van der Poel S., McCabe N.R., Gill H.J., Espinosa R. III, Patel Y., Harden A., Rubinelli P., Smith S.D., Le Beau M.M., Rowley J.D., Diaz M.O.
    Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.
    Proc. Natl. Acad. Sci. U.S.A. 88:10735-10739(1991)

    PubMed=1423625; DOI=10.1016/0092-8674(92)90603-A
    Gu Y., Nakamura T., Alder H., Prasad R., Canaani O., Cimino G., Croce C.M., Canaani E.
    The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene.
    Cell 71:701-708(1992)

    PubMed=1465024; DOI=10.1016/0145-2126(92)90113-L
    Iida S., Saito M., Okazaki T., Seto M., Yamamoto K., Akao Y., Ogura M., Suzuki H., Ariyoshi Y., Koike K., Nitta M., Takahashi T., Ueda R., Nakazawa S.
    Phenotypic and genotypic characterization of 14 leukemia and lymphoma cell lines with 11q23 translocations.
    Leuk. Res. 16:1155-1163(1992)

    PubMed=8353274; DOI=10.1182/blood.V82.4.1080.1080
    Chen C.-S., Hilden J.M., Frestedt J., Domer P.H., Moore R., Korsmeyer S.J., Kersey J.H.
    The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia.
    Blood 82:1080-1085(1993)

    PubMed=8358709
    Hilden J.M., Chen C.-S., Moore R., Frestedt J., Kersey J.H.
    Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the polymerase chain reaction in t(4;11) acute leukemia.
    Cancer Res. 53:3853-3866(1993)

    PubMed=8180386; DOI=10.1182/blood.V83.10.2912.2912
    Yamamoto K., Seto M., Iida S., Komatsu H., Kamada N., Kojima S., Kodera Y., Nakazawa S., Saito H., Takahashi T., Ueda R.
    A reverse transcriptase-polymerase chain reaction detects heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities.
    Blood 83:2912-2921(1994)

    PubMed=9067587; DOI=10.1038/sj.leu.2400571
    Uphoff C.C., MacLeod R.A.F., Denkmann S.A., Golub T.R., Borkhardt A., Janssen J.W.G., Drexler H.G.
    Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.
    Leukemia 11:441-447(1997)

    PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x
    Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T., Aizawa Y., Ueda R., Seto M.
    Expression of the TCL1 gene at 14q32 in B-cell malignancies but not in adult T-cell leukemia.
    Jpn. J. Cancer Res. 89:712-718(1998)

    DOI=10.1016/B978-0-12-221970-2.50457-5
    Drexler H.G.
    The leukemia-lymphoma cell line factsbook.
    (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

    PubMed=14671638; DOI=10.1038/sj.leu.2403236
    Drexler H.G., Quentmeier H., MacLeod R.A.F.
    Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.
    Leukemia 18:227-232(2004)

    PubMed=15843827; DOI=10.1038/sj.leu.2403749
    Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
    Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
    Leukemia 19:1042-1050(2005)

    PubMed=16408098; DOI=10.1038/sj.leu.2404081
    Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
    JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
    Leukemia 20:471-476(2006)

    PubMed=16523483; DOI=10.1002/gcc.20317
    Horsley S.W., Mackay A., Iravani M., Fenwick K., Valgeirsson H., Dexter T.J., Ashworth A., Kearney L.
    Array CGH of fusion gene-positive leukemia-derived cell lines reveals cryptic regions of genomic gain and loss.
    Genes Chromosomes Cancer 45:554-564(2006)

    PubMed=20164919; DOI=10.1038/nature08768
    Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
    Signatures of mutation and selection in the cancer genome.
    Nature 463:893-898(2010)

    PubMed=20922763; DOI=10.1002/pbc.22801
    Kang M.H., Smith M.A., Morton C.L., Keshelava N., Houghton P.J., Reynolds C.P.
    National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.
    Pediatr. Blood Cancer 56:239-249(2011)

    PubMed=21552520; DOI=10.1371/journal.pone.0019169
    Gu T.-L., Nardone J., Wang Y., Loriaux M., Villen J., Beausoleil S.A., Tucker M., Kornhauser J.M., Ren J., MacNeill J., Gygi S.P., Druker B.J., Heinrich M.C., Rush J., Polakiewicz R.D.
    Survey of activated FLT3 signaling in leukemia.
    PLoS ONE 6:E19169-E19169(2011)

    PubMed=22460905; DOI=10.1038/nature11003
    Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
    The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
    Nature 483:603-607(2012)

    PubMed=25984343; DOI=10.1038/sdata.2014.35
    Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
    Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
    Sci. Data 1:140035-140035(2014)

    PubMed=26589293; DOI=10.1186/s13073-015-0240-5
    Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
    TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
    Genome Med. 7:118.1-118.7(2015)

    PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
    Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
    A landscape of pharmacogenomic interactions in cancer.
    Cell 166:740-754(2016)

    PubMed=30285677; DOI=10.1186/s12885-018-4840-5
    Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
    Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
    BMC Cancer 18:940.1-940.13(2018)

    PubMed=30629668; DOI=10.1371/journal.pone.0210404
    Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
    Screening human cell lines for viral infections applying RNA-Seq data analysis.
    PLoS ONE 14:E0210404-E0210404(2019)

    PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
    Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
    An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
    Cancer Res. 79:1263-1273(2019)

    PubMed=31068700; DOI=10.1038/s41586-019-1186-3
    Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
    Next-generation characterization of the Cancer Cell Line Encyclopedia.
    Nature 569:503-508(2019)

    PubMed=32721124; DOI=10.1002/cnr2.1207
    Ragusa D., Makarov E.M., Britten O., Moralli D., Green C.M., Tosi S.
    The RS4;11 cell line as a model for leukaemia with t(4;11)(q21;q23): revised characterisation of cytogenetic features.
    Cancer Rep. 2:e1207.1-e1207.11(2019)

    PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
    Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
    Pan-cancer proteomic map of 949 human cell lines.
    Cancer Cell 40:835-849.e8(2022)

    Cross-references
    Cell line databases/resourcesCLO; CLO_0008883
    Cell_Model_Passport; SIDM01086
    Cosmic-CLP; 909703
    DSMZCellDive; ACC-508
    DepMap; ACH-000874
    LINCS_LDP; LCL-1040
    Lonza; 714
    Anatomy/cell type resourcesBTO; BTO:0004505
    Biological sample resourcesBioSample; SAMN03471039
    BioSample; SAMN03473511
    BioSample; SAMN10987766
    Cell line collections (Providers)AddexBio; C0003012/4671
    ATCC; CRL-1873
    DSMZ; ACC-508
    Chemistry resourcesChEMBL-Cells; CHEMBL3308247
    ChEMBL-Targets; CHEMBL2366159
    GDSC; 909703
    PharmacoDB; RS4_11_1331_2019
    PubChem_Cell_line; CVCL_0093
    Encyclopedic resourcesWikidata; Q54951304

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