• SNU-16人胃癌细胞(STR鉴定正确)

    价 格👩🏿‍🌾:¥1800

    期 货:现货(冻存管发2支)

    保藏中心:BTCC

    资源编号:BTCC-1291

    产地🎮:中国

    套 餐♾:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameSNU-16
    SynonymsSNU16; NCI-SNU-16
    AccessionBTCC-1291
    Resource Identification InitiativeTo cite this cell line use: SNU-16 (BTCC-1291)
    CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
    Part of: COSMIC cell lines project.
    Part of: FGFR genetic alteration cell panel (ATCC TCP-1034).
    Part of: MD Anderson Cell Lines Project.
    Part of: MYC genetic alteration cell panel (ATCC TCP-1035).
    Part of: Seoul National University (SNU) cell line collection.
    Part of: TCGA-110-CL cell line panel.
    Population: Korean.
    Doubling time: 27 hours (ATCC=CRL-5974; PubMed=2158397).
    Microsatellite instability: Stable (MSS) (PubMed=10674020; Sanger).
    Omics: Deep exome analysis.
    Omics: Deep quantitative proteome analysis.
    Omics: DNA methylation analysis.
    Omics: Protein expression by reverse-phase protein arrays.
    Omics: SNP array analysis.
    Omics: Transcriptome analysis by microarray.
    Omics: Transcriptome analysis by RNAseq.
    Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
    Sequence variations
    • Gene fusion; HGNC; 1681; CD44 + HGNC; 10940; SLC1A2; Name(s)=CD44-SLC1A2 (PubMed=23637631).
    • Mutation; HGNC; 7329; MSH6; Simple; p.Lys1358fs*2 (c.4065_4066insTTGA); Zygosity=Heterozygous (Cosmic-CLP; DepMap).
    • Mutation; HGNC; 11998; TP53; Simple; p.Tyr205Phe (c.614A>T); ClinVar=VCV000376682; Zygosity=Homozygous (PubMed=1676761; Cosmic-CLP; DepMap).
    HLA typingSource: PubMed=25960936
    Class I
    HLA-AA*24:02,33:03
    HLA-BB*52:01,55:01
    HLA-CC*01:02,01:02
    Class II
    HLA-DQDQB1*06:13,06:13
    HLA-DRDRB1*13:02,13:02

    Source: PubMed=26589293
    Class I
    HLA-AA*24:02,33:03
    HLA-BB*52:01,55:01
    HLA-CC*01:02,01:02
    Genome ancestrySource: PubMed=30894373

    Origin% genome


    African3.14
    Native American0.82
    East Asian, North65.94
    East Asian, South27.38
    South Asian0
    European, North0
    European, South2.71
    DiseaseGastric adenocarcinoma (NCIt: C4004)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    HierarchyChildren:



    CVCL_L043 (SNU-16-DOX)CVCL_WY37 (SNU-16Ad)CVCL_WY38 (SNU-16alpha5)
    Sex of cellFemale
    Age at sampling33Y
    CategoryCancer cell line
    STR profileSource(s): ATCC; Cosmic-CLP; KCLB; PubMed=25877200

    Markers:
    AmelogeninX
    CSF1PO12
    D3S135815,16
    D5S81810,13
    D7S82012
    D8S117914
    D13S3178,12
    D16S53911,13
    D18S5114,16
    D21S1129,33.2
    FGA23
    Penta D9,12
    Penta E11,17
    TH016,9
    TPOX11
    vWA16

    Run an STR similarity search on this cell line
    Web pageshttps://tcpaportal.org/mclp/
    Publications

    PubMed=2158397
    Park J.-G., Frucht H., La Rocca R.V., Bliss D.P. Jr., Kurita Y., Chen T.-R., Henslee J.G., Trepel J.B., Jensen R.T., Johnson B.E., Bang Y.-J., Kim J.-P., Gazdar A.F.
    Characteristics of cell lines established from human gastric carcinoma.
    Cancer Res. 50:2773-2780(1990)

    PubMed=1676761; DOI=10.1093/jnci/83.13.938
    Kim J.-H., Takahashi T., Chiba I., Park J.-G., Birrer M.J., Roh J.K., De Lee H., Kim J.-P., Minna J.D., Gazdar A.F.
    Occurrence of p53 gene abnormalities in gastric carcinoma tumors and cell lines.
    J. Natl. Cancer Inst. 83:938-943(1991)

    DOI=10.1016/B978-0-12-333530-2.50014-9
    Sekiguchi M., Suzuki T.
    Gastric tumor cell lines.
    (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.287-316; Academic Press; New York (1994)

    PubMed=8806092; DOI=10.1002/jcb.240630505
    Phelps R.M., Johnson B.E., Ihde D.C., Gazdar A.F., Carbone D.P., McClintock P.R., Linnoila R.I., Matthews M.J., Bunn P.A. Jr., Carney D.N., Minna J.D., Mulshine J.L.
    NCI-Navy Medical Oncology Branch cell line data base.
    J. Cell. Biochem. 63 Suppl. 24:32-91(1996)

    PubMed=8806095; DOI=10.1002/jcb.240630508
    Park J.-G., Gazdar A.F.
    Biology of colorectal and gastric cancer cell lines.
    J. Cell. Biochem. 63 Suppl. 24:131-141(1996)

    PubMed=10674020; DOI=10.1016/S0959-8049(99)00206-3
    Ku J.-L., Yoon K.-A., Kim D.-Y., Park J.-G.
    Mutations in hMSH6 alone are not sufficient to cause the microsatellite instability in colorectal cancer cell lines.
    Eur. J. Cancer 35:1724-1729(1999)

    PubMed=14720123; DOI=10.1042/BJ20031408
    Kim H.-P., Lee M.-S., Yu J., Park J.-A., Jong H.-S., Kim T.-Y., Lee J.W., Bang Y.-J.
    TGF-beta1 (transforming growth factor-beta1)-mediated adhesion of gastric carcinoma cells involves a decrease in Ras/ERKs (extracellular-signal-regulated kinases) cascade activity dependent on c-Src activity.
    Biochem. J. 379:141-150(2004)

    PubMed=19956504; DOI=10.4143/crt.2005.37.1.1
    Ku J.-L., Park J.-G.
    Biology of SNU cell lines.
    Cancer Res. Treat. 37:1-19(2005)

    PubMed=20164919; DOI=10.1038/nature08768
    Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
    Signatures of mutation and selection in the cancer genome.
    Nature 463:893-898(2010)

    PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
    Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
    A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
    Cancer Res. 70:2158-2164(2010)

    PubMed=22460905; DOI=10.1038/nature11003
    Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
    The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
    Nature 483:603-607(2012)

    PubMed=23637631; DOI=10.1371/journal.pgen.1003464
    Giacomini C.P., Sun S., Varma S., Shain A.H., Giacomini M.M., Balagtas J.M.S., Sweeney R.T., Lai E., Del Vecchio C.A., Forster A.D., Clarke N., Montgomery K.D., Zhu S., Wong A.J., van de Rijn M., West R.B., Pollack J.R.
    Breakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer types.
    PLoS Genet. 9:E1003464-E1003464(2013)

    PubMed=24807215; DOI=10.1038/ncomms4830
    Liu J.-F., McCleland M.L., Stawiski E.W., Gnad F., Mayba O., Haverty P.M., Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., Liu H.-B., Wan Y.-N., Chopra V.S., Yaylaoglu M.B., Yuan W.-L., Ha C., Gilbert H.N., Reeder J., Pau G., Stinson J., Stern H.M., Manning G., Wu T.D., Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., Firestein R., Zhang Z.-M.
    Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
    Nat. Commun. 5:3830.1-3830.8(2014)

    PubMed=25960936; DOI=10.4161/21624011.2014.954893
    Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
    A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
    OncoImmunology 3:e954893.1-e954893.12(2014)

    PubMed=25485619; DOI=10.1038/nbt.3080
    Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
    A comprehensive transcriptional portrait of human cancer cell lines.
    Nat. Biotechnol. 33:306-312(2015)

    PubMed=26589293; DOI=10.1186/s13073-015-0240-5
    Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
    TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
    Genome Med. 7:118.1-118.7(2015)

    PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
    Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
    A landscape of pharmacogenomic interactions in cancer.
    Cell 166:740-754(2016)

    PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
    Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
    Characterization of human cancer cell lines by reverse-phase protein arrays.
    Cancer Cell 31:225-239(2017)

    PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
    Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
    An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
    Cancer Res. 79:1263-1273(2019)

    PubMed=31068700; DOI=10.1038/s41586-019-1186-3
    Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
    Next-generation characterization of the Cancer Cell Line Encyclopedia.
    Nature 569:503-508(2019)

    PubMed=31395879; DOI=10.1038/s41467-019-11415-2
    Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M., van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
    Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
    Nat. Commun. 10:3574.1-3574.11(2019)

    PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
    Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
    Pan-cancer proteomic map of 949 human cell lines.
    Cancer Cell 40:835-849.e8(2022)

    Cross-references
    Cell line databases/resourcesCLO; CLO_0009095
    Cell_Model_Passport; SIDM01145
    Cosmic-CLP; 908446
    DepMap; ACH-000581
    IGRhCellID; SNU16
    LINCS_LDP; LCL-1889
    Anatomy/cell type resourcesBTO; BTO:0004987
    Biological sample resourcesBioSample; SAMN03473127
    BioSample; SAMN10987911
    Cell line collections (Providers)ATCC; CRL-5974
    BCRC; 60212
    KCLB; 00016
    Chemistry resourcesChEMBL-Cells; CHEMBL3307273
    ChEMBL-Targets; CHEMBL613529
    GDSC; 908446
    PharmacoDB; SNU16_1446_2019
    PubChem_Cell_line; CVCL_0076
    Encyclopedic resourcesWikidata; Q54955122
    Experimental variables resourcesEFO; EFO_0002344

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