• 6T-CEM人T细胞白血病细胞(STR鉴定正确)

    价 格：¥1800

    期 货：现货（冻存管发2支）

    保藏中心：BTCC

    资源编号：BTCC-1368

    产地🎻：中国

    套 餐👦：

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告（COA）

    Cell line name6T-CEM
    Synonyms6-T CEM
    AccessionBTCC-1368
    Resource Identification InitiativeTo cite this cell line use: 6T-CEM (BTCC-1368)
    CommentsGroup: Patented cell line.
    Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-8296.
    Population: Caucasian.
    Selected for resistance to: ChEBI; CHEBI:9555; Tioguanine (6-thioguanine; 6-TG).
    Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
    Cell type: T-cell; CL=CL_0000084.
    Sequence variations
    • Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
    • Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
    • Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
    • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
    • Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
    • Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
    • Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
    • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
    DiseaseChildhood T acute lymphoblastic leukemia (NCIt: C7953)
    Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    HierarchyParent: CVCL_0207 (CCRF-CEM)
    Children:

    CVCL_U293 (6T-CEM20)
    Sex of cellFemale
    Age at sampling3Y11M
    CategoryCancer cell line
    STR profileSource(s): ATCC; CCRID

    Markers:
    AmelogeninX
    CSF1PO10,11
    D2S133824
    D3S135814,15
    D5S81811,12,13 (ATCC)
    11,13 (CCRID)
    D7S8209,14
    D8S117913
    D13S31711,12
    D16S53910,13
    D18S5113,18
    D19S43314,15
    D21S1131,33.2
    FGA23,24
    TH016,7
    TPOX8
    vWA17,19

    Run an STR similarity search on this cell line
    Publications

    Patent=US4705687
    Lau C.Y.
    Treatment of autoimmune diseases such as rheumatoid arthritis with suppressor factor.
    Patent number US4705687, 10-Nov-1987

    Patent=US4728614
    Lau C.Y.
    Mutant human T cell line producing immunosuppressive factor and method for obtaining such mutants.
    Patent number US4728614, 01-Mar-1988

    Cross-references
    Cell line databases/resourcesCCRID; 3101HUMTCHu2
    Biological sample resourcesBioSample; SAMN03471201
    Cell line collections (Providers)ATCC; CRL-8296
    CLS; 305132
    Encyclopedic resourcesWikidata; Q54604612

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