• 5637人膀胱癌细胞(STR鉴定正确)

    价 格🫲🏿:¥1800

    期 货:现货(冻存管发2支)

    保藏中心:BTCC

    资源编号:BTCC-1001

    产地🏊🏻‍♀️:中国

    套 餐🌶:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line name5637
    AccessionBTCC-1001
    Resource Identification InitiativeTo cite this cell line use: 5637 (BTCC-1001)
    CommentsPart of: BLA-40 bladder carcinoma cell line panel.
    Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
    Part of: COSMIC cell lines project.
    Part of: ERK genetic alteration cell panel (ATCC TCP-1033).
    Part of: UBC-40 urothelial bladder cancer cell line index.
    Doubling time: 23 hours (PubMed=26055179); ~24 hours (DSMZ=ACC-35).
    Microsatellite instability: Stable (MSS) (Sanger).
    Omics: Array-based CGH.
    Omics: CNV analysis.
    Omics: Deep exome analysis.
    Omics: Deep quantitative proteome analysis.
    Omics: DNA methylation analysis.
    Omics: GPI-anchored proteins analysis by proteomics.
    Omics: SNP array analysis.
    Omics: Transcriptome analysis by microarray.
    Omics: Transcriptome analysis by RNAseq.
    Misspelling: HTB9; Note=Based on the ATCC catalog number.
    Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
    Sequence variations
    • Mutation; HGNC; 6871; MAPK1; Simple; p.Arg79Lys (c.236G>A); Zygosity=Heterozygous (ATCC; Cosmic-CLP; DepMap).
    • Mutation; HGNC; 9884; RB1; Simple; p.Tyr325Ter (c.975T>A); Zygosity=Homozygous (PubMed=27270441; Cosmic-CLP; DepMap).
    • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=24035680; PubMed=31068700).
    • Mutation; HGNC; 11998; TP53; Simple; p.Arg280Thr (c.839G>C); ClinVar=VCV000012368; Zygosity=Homozygous (PubMed=7787250; PubMed=9850064; Cosmic-CLP; DepMap).
    Genome ancestrySource: PubMed=30894373

    Origin% genome


    African30.56
    Native American0.45
    East Asian, North11.48
    East Asian, South40.31
    South Asian0.35
    European, North4.97
    European, South11.89
    DiseaseBladder carcinoma (NCIt: C4912)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    HierarchyChildren:



    CVCL_6344 (5637 subclone 1A6)CVCL_RR13 (5637rCDDP1000)CVCL_RR14 (5637rGEMCI20)
    CVCL_JE91 (H/Rb-CL2)CVCL_JE92 (H/Rb-M)
    Sex of cellMale
    Age at sampling68Y
    CategoryCancer cell line
    STR profileSource(s): ATCC; CCRID; CLS; Cosmic-CLP; DSMZ; KCLB; PubMed=11416159; PubMed=17254797; PubMed=27270441; RCB; TKG

    Markers:
    AmelogeninX,Y
    CSF1PO11
    D1S165615
    D2S133825
    D3S135815,17
    D5S81811,12
    D6S104316,20
    D7S82010,11
    D8S117910,16
    D12S39120
    D13S31711
    D16S5399
    D18S5116,18
    D19S43313,15
    D21S1136
    FGA22
    Penta D11
    Penta E10,12
    TH017,9
    TPOX8,9
    vWA16,18 (ATCC; Cosmic-CLP; PubMed=27270441; TKG)
    18 (CCRID; CLS; DSMZ; KCLB; PubMed=11416159; PubMed=17254797; RCB)

    Run an STR similarity search on this cell line
    Web pageshttp://www.cells-talk.com/index.php/page/copelibrary?key=5637
    https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/5/cell-lines-detail-354.html
    https://www.synapse.org/UC25
    Publications

    PubMed=327080; DOI=10.1093/jnci/59.1.221
    Fogh J., Fogh J.M., Orfeo T.
    One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
    J. Natl. Cancer Inst. 59:221-226(1977)

    PubMed=833871; DOI=10.1093/jnci/58.2.209
    Fogh J., Wright W.C., Loveless J.D.
    Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
    J. Natl. Cancer Inst. 58:209-214(1977)

    PubMed=571047
    Fogh J.
    Cultivation, characterization, and identification of human tumor cells with emphasis on kidney, testis, and bladder tumors.
    Natl. Cancer Inst. Monogr. 49:5-9(1978)

    PubMed=6244232
    Williams R.D.
    Human urologic cancer cell lines.
    Invest. Urol. 17:359-363(1980)

    PubMed=7459858
    Rousset M., Zweibaum A., Fogh J.
    Presence of glycogen and growth-related variations in 58 cultured human tumor cell lines of various tissue origins.
    Cancer Res. 41:1165-1170(1981)

    PubMed=6582512; DOI=10.1073/pnas.81.2.568
    Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
    Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
    Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

    PubMed=3518877; DOI=10.3109/07357908609038260
    Fogh J.
    Human tumor lines for cancer research.
    Cancer Invest. 4:157-184(1986)

    PubMed=7787250
    Cooper M.J., Haluschak J.J., Johnson D., Schwartz S., Morrison L.J., Lippa M., Hatzivassiliou G., Tan J.
    p53 mutations in bladder carcinoma cell lines.
    Oncol. Res. 6:569-579(1994)

    PubMed=8873383; DOI=10.1007/BF00295899
    Stadler W.M., Olopade O.I.
    The 9p21 region in bladder cancer cell lines: large homozygous deletion inactivate the CDKN2, CDKN2B and MTAP genes.
    Urol. Res. 24:239-244(1996)

    PubMed=9850064
    Markl I.D.C., Jones P.A.
    Presence and location of TP53 mutation determines pattern of CDKN2A/ARF pathway inactivation in bladder cancer.
    Cancer Res. 58:5348-5353(1998)

    PubMed=11921286; DOI=10.1002/gcc.10050
    Williams S.V., Sibley K.D., Davies A.M., Nishiyama H., Hornigold N., Coulter J., Kennedy W.J., Skilleter A., Habuchi T., Knowles M.A.
    Molecular genetic analysis of chromosome 9 candidate tumor-suppressor loci in bladder cancer cell lines.
    Genes Chromosomes Cancer 34:86-96(2002)

    PubMed=12127398; DOI=10.1016/S0165-4608(01)00648-3
    Strefford J.C., Lillington D.M., Steggall M., Lane T.M., Nouri A.M.E., Young B.D., Oliver R.T.D.
    Novel chromosome findings in bladder cancer cell lines detected with multiplex fluorescence in situ hybridization.
    Cancer Genet. Cytogenet. 135:139-146(2002)

    PubMed=15846775; DOI=10.1002/gcc.20166
    Williams S.V., Adams J., Coulter J., Summersgill B.M., Shipley J.M., Knowles M.A.
    Assessment by M-FISH of karyotypic complexity and cytogenetic evolution in bladder cancer in vitro.
    Genes Chromosomes Cancer 43:315-328(2005)

    PubMed=16885334; DOI=10.1158/0008-5472.CAN-06-1182
    Lopez-Knowles E., Hernandez S., Malats N., Kogevinas M., Lloreta J., Carrato A., Tardon A., Serra C., Real F.X.
    PIK3CA mutations are an early genetic alteration associated with FGFR3 mutations in superficial papillary bladder tumors.
    Cancer Res. 66:7401-7404(2006)

    PubMed=17254797; DOI=10.1016/j.biologicals.2006.10.001
    Azari S., Ahmadi N., Tehrani M.J., Shokri F.
    Profiling and authentication of human cell lines using short tandem repeat (STR) loci: report from the National Cell Bank of Iran.
    Biologicals 35:195-202(2007)

    PubMed=20164919; DOI=10.1038/nature08768
    Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
    Signatures of mutation and selection in the cancer genome.
    Nature 463:893-898(2010)

    PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
    Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
    A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
    Cancer Res. 70:2158-2164(2010)

    PubMed=22460905; DOI=10.1038/nature11003
    Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
    The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
    Nature 483:603-607(2012)

    PubMed=23401075; DOI=10.1002/path.4176
    Guo Y., Chekaluk Y., Zhang J., Du J., Gray N.S., Wu C.-L., Kwiatkowski D.J.
    TSC1 involvement in bladder cancer: diverse effects and therapeutic implications.
    J. Pathol. 230:17-27(2013)

    PubMed=24367658; DOI=10.1371/journal.pone.0084411
    Ross R.L., Burns J.E., Taylor C.F., Mellor P., Anderson D.H., Knowles M.A.
    Identification of mutations in distinct regions of p85 alpha in urothelial cancer.
    PLoS ONE 8:E84411-E84411(2013)

    PubMed=24035680; DOI=10.1016/j.eururo.2013.08.057
    Hurst C.D., Platt F.M., Knowles M.A.
    Comprehensive mutation analysis of the TERT promoter in bladder cancer and detection of mutations in voided urine.
    Eur. Urol. 65:367-369(2014)

    PubMed=24459064; DOI=10.1007/s13277-013-1604-3
    Pinto-Leite R., Carreira I., Melo J., Ferreira S.I., Ribeiro I., Ferreira J., Filipe M., Bernardo C., Arantes-Rodrigues R., Oliveira P., Santos L.
    Genomic characterization of three urinary bladder cancer cell lines: understanding genomic types of urinary bladder cancer.
    Tumor Biol. 35:4599-4617(2014)

    PubMed=25997541; DOI=10.1186/s12864-015-1450-3
    Earl J., Rico D., Carrillo-de-Santa-Pau E., Rodriguez-Santiago B., Mendez-Pertuz M., Auer H., Gomez G., Grossman H.B., Pisano D.G., Schulz W.A., Perez-Jurado L.A., Carrato A., Theodorescu D., Chanock S.J., Valencia A., Real F.X.
    The UBC-40 Urothelial Bladder Cancer cell line index: a genomic resource for functional studies.
    BMC Genomics 16:403.1-403.16(2015)

    PubMed=26055179; DOI=10.1016/j.tranon.2015.04.002
    Vallo S., Michaelis M., Rothweiler F., Bartsch G., Gust K.M., Limbart D.M., Rodel F., Wezel F., Haferkamp A., Cinatl J. Jr.
    Drug-resistant urothelial cancer cell lines display diverse sensitivity profiles to potential second-line therapeutics.
    Transl. Oncol. 8:210-216(2015)

    PubMed=26972028; DOI=10.1016/j.jprot.2016.03.008
    Masuishi Y., Kimura Y., Arakawa N., Hirano H.
    Identification of glycosylphosphatidylinositol-anchored proteins and omega-sites using TiO2-based affinity purification followed by hydrogen fluoride treatment.
    J. Proteomics 139:77-83(2016)

    PubMed=27141528; DOI=10.1016/j.dib.2016.04.001
    Masuishi Y., Kimura Y., Arakawa N., Hirano H.
    Data for identification of GPI-anchored peptides and omega-sites in cancer cell lines.
    Data Brief 7:1302-1305(2016)

    PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
    Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
    A landscape of pharmacogenomic interactions in cancer.
    Cell 166:740-754(2016)

    PubMed=27270441; DOI=10.1038/onc.2016.172
    Nickerson M.L., Witte N., Im K.M., Turan S., Owens C., Misner K., Tsang S.X., Cai Z., Wu S., Dean M., Costello J.C., Theodorescu D.
    Molecular analysis of urothelial cancer cell lines for modeling tumor biology and drug response.
    Oncogene 36:35-46(2017)

    PubMed=29732388; DOI=10.3233/BLC-180167
    Zuiverloon T.C.M., de Jong F.C., Costello J.C., Theodorescu D.
    Systematic review: characteristics and preclinical uses of bladder cancer cell lines.
    Bladder Cancer 4:169-183(2018)

    PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
    Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
    An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
    Cancer Res. 79:1263-1273(2019)

    PubMed=31068700; DOI=10.1038/s41586-019-1186-3
    Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
    Next-generation characterization of the Cancer Cell Line Encyclopedia.
    Nature 569:503-508(2019)

    PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
    Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
    Pan-cancer proteomic map of 949 human cell lines.
    Cancer Cell 40:835-849.e8(2022)

    Cross-references
    Cell line databases/resourcesCLO; CLO_0001421
    CLO; CLO_0050845
    MCCL; MCC:0000018
    CLDB; cl1
    CLDB; cl105
    CLDB; cl7118
    CCRID; 1101HUM-PUMC000242
    CCRID; 3101HUMTCHu01
    CCRID; 3101HUMTCHu1
    Cell_Model_Passport; SIDM00807
    Cosmic-CLP; 687452
    DepMap; ACH-000905
    DSMZCellDive; ACC-35
    IGRhCellID; 5637
    LINCS_HMS; 50001
    LINCS_LDP; LCL-1702
    SKY/M-FISH/CGH; 17
    Anatomy/cell type resourcesBTO; BTO:0003137
    Biological sample resourcesBioSample; SAMN01821610
    BioSample; SAMN03472760
    BioSample; SAMN03473359
    BioSample; SAMN10987658
    Cell line collections (Providers)AddexBio; C0002001/8
    ATCC; HTB-9
    BCRC; 60061
    BCRJ; 0026
    CLS; 300105
    DSMZ; ACC-35
    ICLC; HTL01017
    KCLB; 30009
    NCBI_Iran; C450
    RCB; RCB1191
    RCB; RCB3676
    TKG; TKG 0605
    Chemistry resourcesChEMBL-Cells; CHEMBL3308352
    ChEMBL-Targets; CHEMBL612565
    GDSC; 687452
    PharmacoDB; 5637_20_2019
    PubChem_Cell_line; CVCL_0126
    Encyclopedic resourcesWikidata; Q54603866
    Experimental variables resourcesEFO; EFO_0002096
    Gene expression databasesArrayExpress; E-MTAB-38
    ArrayExpress; E-MTAB-783
    ArrayExpress; E-MTAB-2770
    ArrayExpress; E-MTAB-3610
    GEO; GSM136228
    GEO; GSM142303
    GEO; GSM142309
    GEO; GSM886840
    GEO; GSM887903
    GEO; GSM1374370
    GEO; GSM1574578
    GEO; GSM1669563
    Polymorphism and mutation databasesCosmic; 687452
    Cosmic; 715695
    Cosmic; 760484
    Cosmic; 845565
    Cosmic; 846281
    Cosmic; 928819
    Cosmic; 943732
    Cosmic; 1016892
    Cosmic; 1046675
    Cosmic; 1093983
    Cosmic; 1285103
    Cosmic; 1285998
    Cosmic; 1927307
    Cosmic; 2050427
    Cosmic; 2057434
    Cosmic; 2301520
    Cosmic; 2444227
    Cosmic; 2685930
    Cosmic; 2700995
    IARC_TP53; 3717
    LiGeA; CCLE_867
    Progenetix; CVCL_0126
    Proteomic databasesPRIDE; PXD003105
    PRIDE; PXD030304
    Sequence databasesEGA; EGAS00001000978
    Entry history
    Entry creation04-Apr-2012
    Last entry update29-Jun-2023
    Version number44


    更多>>相关产品

    总部地址:北京市怀柔区渤海镇怀沙路536号

    关注杏鑫
    在线咨询
    在线客服
    电话咨询
    微信客服
    返回顶部
    杏鑫娱乐专业提供✉️:杏鑫娱乐🩸、杏鑫杏鑫平台等服务,提供最新官网平台、地址、注册、登陆、登录、入口、全站、网站、网页、网址、娱乐、手机版、app、下载、欧洲杯、欧冠、nba、世界杯、英超等,界面美观优质完美,安全稳定,服务一流🚶🏻‍♀️‍➡️,杏鑫娱乐欢迎您。