BCPAP人甲状腺癌乳头状细胞(STR鉴定正确)

    价 格:¥1800

    期 货:现货(冻存管发2支)

    保藏中心:BTCC

    资源编号🦸🏻:BTCC-1020

    产地:中国

    套 餐:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameB-CPAP
    SynonymsBC-PAP; BCPAP
    AccessionBTCC-1020
    Resource Identification InitiativeTo cite this cell line use: B-CPAP (BTCC-1020)
    CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
    Part of: COSMIC cell lines project.
    Part of: TCGA-110-CL cell line panel.
    Population: Caucasian.
    Doubling time: ~30 hours (DSMZ=ACC-273).
    Microsatellite instability: Stable (MSS) (Sanger).
    Omics: Deep exome analysis.
    Omics: Deep quantitative proteome analysis.
    Omics: DNA methylation analysis.
    Omics: SNP array analysis.
    Omics: Transcriptome analysis by microarray.
    Omics: Transcriptome analysis by RNAseq.
    Caution: Originally classified a thyroid gland papillary carcinoma (PTC) but is now considered to be a poorly differentiated thyroid gland carcinoma (PDTC) (PubMed=23162534).
    Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
    Sequence variations
    HLA typingSource: PubMed=26589293
    Class I
    HLA-AA*02:01,33:01
    HLA-BB*18:01,35:01
    HLA-CC*04:01,07:01
    Genome ancestrySource: PubMed=30894373

    Origin% genome


    African0.56
    Native American1.26
    East Asian, North0.45
    East Asian, South1.09
    South Asian1.92
    European, North43.75
    European, South50.97
    DiseasePoorly differentiated thyroid gland carcinoma (NCIt: C6040)
    Thyroid carcinoma (ORDO: Orphanet_100088)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    HierarchyChildren:

    CVCL_A8S1 (BCPAP-R)
    Sex of cellFemale
    Age at sampling76Y
    CategoryCancer cell line
    STR profileSource(s): Cosmic-CLP; DSMZ; PubMed=18713817; PubMed=21868764; PubMed=25877200; PubMed=30737244

    Markers:
    AmelogeninX
    CSF1PO13
    D2S133818
    D3S135816,17
    D5S81810,11
    D7S82010
    D8S117912,13
    D13S31712
    D16S53911,12
    D18S5113,17
    D19S43313.2,15
    14,15
    D21S1130 (DSMZ)
    30,31.2 (PubMed=18713817; PubMed=25877200; PubMed=30737244)
    FGA20,23
    Penta D10,11
    Penta E5,12 (DSMZ)
    5,12,17 (PubMed=25877200)
    TH016,9.3
    TPOX8,11
    vWA14,17

    Run an STR similarity search on this cell line
    Publications

    PubMed=1297527
    Paulin C., Fabien N., Fusco A., Pages M.-P., Patricot M.-C., Bornet H., Dubois P.-M.
    Description of a cell line established from a human thyroid papillary carcinoma and synthesizing human chorionic gonadotropin hormone.
    C. R. Acad. Sci. III, Sci. Vie 315:493-498(1992)

    PubMed=8156527; DOI=10.1002/1097-0142(19940415)73:8<2206::aid-cncr2820730828>3.0.CO;2-M
    Fabien N., Fusco A., Santoro M., Barbier Y., Dubois P.-M., Paulin C.
    Description of a human papillary thyroid carcinoma cell line Morphologic study and expression of tumoral markers.
    Cancer 73:2206-2212(1994)

    PubMed=11439348; DOI=10.1038/sj.onc.1204531
    Frasca F., Vigneri P., Vella V., Vigneri R., Wang J.Y.J.
    Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to hepatocyte growth factor.
    Oncogene 20:3845-3856(2001)

    PubMed=14522906
    Frasca F., Vella V., Aloisi A., Mandarino A., Mazzon E., Vigneri R., Vigneri P.
    p73 tumor-suppressor activity is impaired in human thyroid cancer.
    Cancer Res. 63:5829-5837(2003)

    PubMed=15172756; DOI=10.1016/j.cancergencyto.2003.09.023
    Dettori T., Frau D.V., Garcia J.L., Pierantoni G.M., Lee C., Hernandez J.M., Fusco A., Morton C.C., Vanni R.
    Comprehensive conventional and molecular cytogenetic characterization of B-CPAP, a human papillary thyroid carcinoma-derived cell line.
    Cancer Genet. Cytogenet. 151:171-177(2004)

    PubMed=17725429; DOI=10.1089/thy.2007.0097
    Meireles A.M., Preto A., Rocha A.S., Rebocho A.P., Maximo V., Pereira-Castro I., Moreira S., Feijao T., Botelho T., Marques R., Trovisco V., Cirnes L., Alves C., Velho S., Soares P., Sobrinho-Simoes M.
    Molecular and genotypic characterization of human thyroid follicular cell carcinoma-derived cell lines.
    Thyroid 17:707-715(2007)

    PubMed=17804723; DOI=10.1158/0008-5472.CAN-06-4026
    van Staveren W.C.G., Solis D.W., Delys L., Duprez L., Andry G., Franc B., Thomas G., Libert F., Dumont J.E., Detours V., Maenhaut C.
    Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype.
    Cancer Res. 67:8113-8120(2007)

    PubMed=18713817; DOI=10.1210/jc.2008-1102
    Schweppe R.E., Klopper J.P., Korch C.T., Pugazhenthi U., Benezra M., Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A. III, Smallridge R.C., Haugen B.R.
    Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
    J. Clin. Endocrinol. Metab. 93:4331-4341(2008)

    PubMed=19087340; DOI=10.1186/1471-2407-8-371
    Ribeiro F.R., Meireles A.M., Rocha A.S., Teixeira M.R.
    Conventional and molecular cytogenetics of human non-medullary thyroid carcinoma: characterization of eight cell line models and review of the literature on clinical samples.
    BMC Cancer 8:371.1-371.11(2008)

    PubMed=20164919; DOI=10.1038/nature08768
    Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
    Signatures of mutation and selection in the cancer genome.
    Nature 463:893-898(2010)

    PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
    Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
    Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
    Clin. Cancer Res. 17:7248-7264(2011)

    PubMed=22087789; DOI=10.1186/1755-8166-4-26
    Maric I., Viaggi S., Caria P., Frau D.V., Degan P., Vanni R.
    Centrosomal and mitotic abnormalities in cell lines derived from papillary thyroid cancer harboring specific gene alterations.
    Mol. Cytogenet. 4:26.1-26.8(2011)

    PubMed=22460905; DOI=10.1038/nature11003
    Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
    The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
    Nature 483:603-607(2012)

    PubMed=23162534; DOI=10.3389/fendo.2012.00133
    Saiselet M., Floor S., Tarabichi M., Dom G., Hebrant A., van Staveren W.C.G., Maenhaut C.
    Thyroid cancer cell lines: an overview.
    Front. Endocrinol. 3:133.1-133.9(2012)

    PubMed=23833040; DOI=10.1210/jc.2013-2383
    Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.
    Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
    J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

    PubMed=26589293; DOI=10.1186/s13073-015-0240-5
    Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
    TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
    Genome Med. 7:118.1-118.7(2015)

    PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
    Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
    A landscape of pharmacogenomic interactions in cancer.
    Cell 166:740-754(2016)

    PubMed=28775782; DOI=10.7150/jca.18855
    Caria P., Pillai R., Dettori T., Frau D.V., Zavattari P., Riva G., Romano G., Pani F., Bentivegna A., Giovannoni R., Pagni F., Sogos V., Vanni R.
    Thyrospheres from B-CPAP cell line with BRAF and TERT promoter mutations have different functional and molecular features than parental cells.
    J. Cancer 8:1629-1639(2017)

    PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953
    Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C., Copland J.A. III, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
    Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
    Clin. Cancer Res. 25:3141-3151(2019)

    PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
    Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
    An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
    Cancer Res. 79:1263-1273(2019)

    PubMed=31068700; DOI=10.1038/s41586-019-1186-3
    Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
    Next-generation characterization of the Cancer Cell Line Encyclopedia.
    Nature 569:503-508(2019)

    PubMed=31395879; DOI=10.1038/s41467-019-11415-2
    Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M., van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
    Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
    Nat. Commun. 10:3574.1-3574.11(2019)

    PubMed=32666385; DOI=10.1007/s12020-020-02417-y
    Run L., Wang L.-P., Nong X.-T., Li N., Huang X., Xiao Y.
    Involvement of HMGB1 in vemurafenib resistance in thyroid cancer cells harboring BRAF (V600E) mutation by regulating excessive autophagy.
    Endocrine 71:418-426(2021)

    PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
    Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
    Pan-cancer proteomic map of 949 human cell lines.
    Cancer Cell 40:835-849.e8(2022)

    Cross-references
    Cell line databases/resourcesCLO; CLO_0001906
    MCCL; MCC:0000045
    CCRID; 3101HUMSCSP543
    Cell_Model_Passport; SIDM00992
    Cosmic-CLP; 924104
    DepMap; ACH-000456
    DSMZCellDive; ACC-273
    LINCS_LDP; LCL-1687
    Anatomy/cell type resourcesBTO; BTO:0004736
    Biological sample resourcesBioSample; SAMN03471001
    BioSample; SAMN10989558
    Cell line collections (Providers)CLS; 305081
    DSMZ; ACC-273
    NCBI_Iran; C596
    Chemistry resourcesChEMBL-Cells; CHEMBL3308356
    ChEMBL-Targets; CHEMBL1075394
    GDSC; 924104
    PharmacoDB; BCPAP_82_2019
    PubChem_Cell_line; CVCL_0153
    Encyclopedic resourcesWikidata; Q54752132
    Gene expression databasesArrayExpress; E-MTAB-783
    ArrayExpress; E-MTAB-2770
    ArrayExpress; E-MTAB-3610
    GEO; GSM886875
    GEO; GSM887940
    GEO; GSM1669612
    Polymorphism and mutation databasesCosmic; 755292
    Cosmic; 849970
    Cosmic; 924104
    Cosmic; 928836
    Cosmic; 931241
    Cosmic; 1084279
    Cosmic; 1162847
    Cosmic; 1237447
    Cosmic; 1239965
    Cosmic; 1280047
    Cosmic; 1507369
    Cosmic; 1533552
    Cosmic; 1536122
    Cosmic; 1889007
    Cosmic; 2036692
    Cosmic; 2054086
    Cosmic; 2319847
    Cosmic; 2613253
    Cosmic; 2791089
    IARC_TP53; 25011
    LiGeA; CCLE_362
    Progenetix; CVCL_0153
    Proteomic databasesPRIDE; PXD030304
    Sequence databasesEGA; EGAS00001000978
    Entry history
    Entry creation04-Apr-2012
    Last entry update29-Jun-2023
    Version number38

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